Microwave Promoted Synthesis of a Rehabilitated Drug: Thalidomide
- Seijas, Julio 1
- Vázquez-Tato, M. 1
- González-Bande, Cristóbal 1
- Martínez, M. 1
- Pacios-López, Beatriz 1
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1
Universidade de Santiago de Compostela
info
ISSN: 0039-7881, 1437-210X
Year of publication: 2004
Volume: 2001
Issue: 07
Type: Article
More publications in: Synthesis
Abstract
A new direct synthesis of thalidomide in high yield by microwave irradiation of N-phthaloyl-l-glutamic in the presence of thiourea is described. Thalidomide was also obtained in good yield from l-glutamic acid, phtalic anhydride and thiourea in a one-pot procedure.