Hydrogen sulphide synthesis is impaired in osteoarthritic chondrocytes from diabetic patients and in vitro in cells exposed to high glucose stress

  1. C. Vaamonde-García 1
  2. E.F. Burguera 2
  3. F.J. Blanco 1
  4. R. Meijide Failde 1
  1. 1 Cell Therapy and Regenerative Medicine Group, Department of Medicine, University of A Coruña, A Coruña, Spain
  2. 2 Tissue Engineering Unit, Rheumatology Research Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Revista:
Boletín de la Sociedad Española de Hidrología Médica

ISSN: 0214-2813

Año de publicación: 2018

Número: 1

Páginas: 92-93

Tipo: Artículo

DOI: 10.23853/BSEHM.2018.0603 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Boletín de la Sociedad Española de Hidrología Médica

Resumen

Background: A growing number of findings support the hypothesis that type 2 diabetes is an independent risk factor of osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Hydrogen sulfide (H2S) plays an important role in the pathogenesis of diabetes and its complications. In relation, we and other authors have observed a protective impact of H2S induction on activation of pathological pathways in the chondrocyte (1).

Fuente de los datos: Dialnet